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Full
peer-reviewed papers and
chapters:
 Llorente-Garcia I, Lenn T, Erhardt H, Harriman OL, Liu L-N, Robson A, Chiu S-W,
Matthews S, Willis NJ, Bray CD, Lee S-H, Shin J Y, Bustamante C, Liphardt J,
Friedrich T, Mullineaux CW and Leake MC. BBA-Bioenergetics (2014).
Single-molecule in vivo imaging of bacterial respiratory complexes
indicates delocalized oxidativce phosphorylation. In Press.
2003
2004
2005
2006
2007
2008 2009
2010
2011
2012
2013
2014:
Chiu
SW, Roberts MA, Leake MC & Armitage JP. Positioning of chemosensory proteins and
FtsZ through the Rhodobacter sphaeroides cell cycle. Mol Microbiol.
(2013) 90:322-337.
 
Leake
MC . Single-molecule
cellular biophysics. Cambridge University Press, 1st Ed. (2013) In Press.
Leake
MC (Compiler and Editor). Single
molecule cellular biophysics: combining physics, biochemistry and cell biology
to study the individual molecules of life. Phil Trans B. (2013) In
Press.
Stream Youtube podcast
Leake
MC. The
physics of life: one molecule at a time. Phil Trans B. (2013) In Press.
Robson
A, Burrage K &
Leake MC. Inferring
diffusion in single live cells at the single molecule level. Phil Trans B.
(2013) In Press.
Badrinarayanan
A, Reyes-Lamothe R, Uphoff S, Leake MC & Sherratt DJ. In vivo
architecture and action of bacterial structural maintenance of chromosome
proteins. Science 338, 528-531 (2012).
SI
Science
EditorialOU
Press release
Lenn T &
Leake MC.
Experimental
approaches for addressing fundamental biological questions in living,
functioning cells with single molecule precision. Open Biol.
(2012),
2,
120090. [Featured Article of the Month].
Harriman OLJ
& Leake MC.
Single molecule experimentation in biological
physics: exploring the living component of soft condensed matter one molecule at
a time. J. Phys.: Condens. Matter (2011),
23, 503101.
Chiu S-W & Leake MC. Functioning nanomachines seen in real-time in living
bacteria using single-molecule and super-resolution fluorescence imaging.
Int. J. Mol. Sci. 2011, 12,
2518-2542.
Xue Q, Harriman O & Leake MC.
Using bespoke fluorescence microscopy
to study the soft condensed matter of living cells at the single molecule level.
J. Phys:
Conf Ser.
2011,
286 012001.
Leake MC.
Shining the spotlight on functional molecular
complexes: The new science of single-molecule cell biology.
Commun
Integr Biol.
2010, 3, 415-418.
Reyes-Lamothe
R, Sherratt DJ, Leake MC.
Stoichiometry and architecture of active DNA
replication machinery in Escherichia coli. Science.
2010, 328, 498-501.
SI
Science
EditorialFaculty
of 1000 Biology Evaluation
Delalez
NJ, Wadhams GH, Rosser G, Xue Q, Brown MT, Dobbie IM, Berry RM, Leake MC,
Armitage JP. Signal-dependent turnover of the bacterial flagellar switch protein
FliM. Proc Natl Acad Sci U S A. 2010, 107, 11347-11351.
SI
 Movie1
Movie2
Movie3
Xue Q,
Jones NS and Leake MC. A
general approach for segmenting elongated and stubby biological objects:
extending a chord length transform with the radon transform.
Proc. IEEE Internat. Symp. Biomed. Imaging (ISBI): From Nano to Macro,
2010, 161-164.
Dobbie IM, Robson A, Delalez N, Leake MC. Visualizing Single Molecular Complexes
In Vivo Using Advanced Fluorescence Microscopy. J Vis Exp. 2009,
31, 1508.
Protocol
Movie
Xue Q and Leake MC. A novel multiple particle tracking algorithm for noisy in
vivo data by minimal path optimization within the spatio-temporal volume.
Proc. IEEE Internat. Symp. Biomed. Imaging (ISBI): From Nano to Macro,
2009, 1158-1161.
Plank M, Wadhams GH,
Leake MC.
Millisecond
timescale slimfield imaging and automated quantification of single fluorescent
protein molecules for use in probing complex biological processes.
Integr. Biol.,
2009, 1, 602-612.
Pilizota T, Brown MT, Leake
MC, Branch RW, Berry RM and Armitage JP. A molecular brake, not a clutch, stops
the Rhodobacter sphaeroides flagellar motor. 2009.
Proc Natl Acad
Sci U S A,
Epub ahead of print.
SI.
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013
2014:
Lenn T*, Leake MC* and
Mullineaux CW. Clustering and dynamics of cytochrome bd-I complexes in the
Escherichia coli plasma membrane in vivo. 2008. Mol. Microbiol, 70,
1397-1407.
SI.
*Joint 1st authors.
Leake
MC*, Greene NP, Godun RM, Granjon T, Buchanan G, Chen S, Berry RM & Berks BC.
Variable stoichiometry of the TatA component of the twin-arginine protein
transport system observed by in vivo single-molecule imaging. 2008.
Proc Natl Acad
Sci U S A, 105,
15376-15381.
SI
*Corresponding author.
Lenn
T, Leake MC & Mullineaux CW. Are Escherichia coli OXPHOS complexes
concentrated in specialized zones within the plasma membrane. 2008.
Biochem Soc Trans, 36, 1032-6.
Leake
MC, Wadhams GH & Armitage JA.
Parts exchange: why molecular machines are like used cars. 2008.
Biologist
55, 33-39.
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013
2014:
Lo CJ, Leake, MC, Pilizota, T & Berry RM.
Single-cell
measurements of Membrane Potential, Sodium-Motive Force and Flagellar Motor
Speed in Escherichia coli.
2007. Biophys. J. 93, 294-302.
SI
Leake MC, Chandler JH,
Wadhams GH, Fan, B, Berry RM & Armitage JA. Stoichiometry and turnover in single, functioning membrane protein complexes. 2006.
Nature
443, 355-8
(2006).
SI
Movies
Cover
Art.
Reid,
SW, Leake, MC, Chandler, JH,
Lo, CJ, Armitage, JP & Berry,
RM. The bacterial flagellar motor
contains at least 11 torque-generating units.
2006.
Proc Natl Acad
Sci U S A
103, 8066-71.
Leake
MC, Gruetzner, A, Krueger, M
& Linke WA. Mechanical
properties of
cardiac titin's N2B region by single molecule atomic force
spectroscopy. 2006. J. Struct Biol.
155, 263-272.
Bullard B, Benes V,
Tzintzuni G, Leake MC, Linke WA & Oberhauser AF. The molecular elasticity of the
insect flight muscle proteins projectin and kettin. 2006.
Proc Natl Acad
Sci U S A
101, 4451-4456.
SI
Lo CJ, Leake MC & Berry
RM. Fluorescence measurement of intracellular sodium concentration in single
Escherichia coli cells. 2006.
Biophys. J.
,
90, 357-65
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013:
Sowa Y, Rowe AD, Leake MC, Yakushi T, Homma M,
Ishijima A & Berry RM. Direct observation of steps in rotation of the bacterial flagellar motor. 2005.
Nature.
437, 916-919.SI
Movie
JST
Press Release EMBO
Commentary
Cover
Art.
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013
2014:
Linke, WA. and
Leake, MC. 2004. Multiple sources of passive stress relaxation in muscle
fibres. Phys. Med. Biol.
49, 3613-3627.
Makarenko,
I, Opitz,
CA, Leake,
MC,
Neagoe,
C, Kulke, M,
Gwathmey,
JK, del Monte, F,
Hajjar, RJ
and
Linke, WA. 2004. Passive stiffness changes of compliant titin isoforms in human DCM hearts. Circ. Res.
95(7):708-16.
SI
Leake MC., Wilson
D., Gautel M. and Simmons RM. 2004. The elasticity of single titin molecules
using a two-bead optical tweezers assay. Biophys. J. 87(2):1112-1135.
SI
Bullard, B., Leake, MC. and Leonard, K. 2004. Some functions of
proteins from the Drosophila sallimus (sls) gene. In "Nature's versatile engine: Insect flight muscle
inside and out", Landes Bioscience, Ed. Jim Vigoreaux, 177-186.
Opitz, CA., Leake, MC., Makarenko, I., Benes, V.
and Linke, WA. 2004. Developmentally
regulated switching of titin size alters myofibrillar stiffness in the
perinatal heart. Circ. Res.
94:967-75.
SI,Ed
Bullard B., Ferguson C., Minajeva A., Leake MC., Gautel M., Labeit D.,
Ding L., Labeit S., Horwitz J., Leonard KR., Linke WA. 2004.
Association of
the chaperone {alpha}B-crystallin with titin in heart muscle.
J Biol Chem.,
279:7917-7924.
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013
2014:
Opitz CA., Kulke
M., Leake MC., Neagoe C., Hinssen H., Hajjar RJ. and Linke WA. 2003.
Damped elastic
recoil of the titin spring in myofibrils of human myocardium.
Proc Natl Acad
Sci U S A., 100:12688-93.
SI
Leake, MC.,
Wilson, D., Bullard, B. and Simmons, RM. The elasticity of single kettin
molecules using a two-bead laser-tweezers assay. 2003. FEBS Lett.,
535(1-3), 55-60.
Rowe, A., Leake,
MC., Morgan, H. and Berry, RM. 2003. Rapid rotation of micron and sub-micron
dielectric particles measured using optical tweezers. J. Mod. Opt.
50(10), 1539-1555.
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