Current Position

Co-Director

Oxford Martin Institute of Nanoscience for Medicine

Department of Physics.

University of Oxford

Associated Member of the Royal Society of Medicine. London UK

2007/08

Sonia Trigueros and Joaquim Roca.

Production of highly knotted DNA by means of cosmid circularization inside phage capsids

BMC Biotechnology 2007.

2009

Sonia Trigueros, Tung Tran, Nohemy Sorto, Jason Newmark, Sean D. Colloms, David J. Sherratt and Marcelo E. Tolmasky

mwr Xer site-specific recombination is hypersensitive to DNA supercoiling

Nucleic Acids Research, 2009, Vol. 37, No. 11 3580-3587

Received October 29, 2008. Revised February 24, 2009. Accepted March 11, 2009.

Corresponding Author.

2006

Duyen Bui, Judianne Ramiscal, Sonia Trigueros, Jason Newmark, Albert Do, David Sherratt and Marcelo Tolmasky.

Differences in resolution of mrw-containing plasmid dimmers mediated by Klebsiella pneumoniae and Escherichia coli XerC recombinases.

J. Bacteriol.188, 2812-2820 (2006).

2005

Javier Arsuaga, Mariel Vazquez, Paul Mc Guirk, Sonia Trigueros, De Witt Sumners, and Joaquim Roca.

DNA knots reveal a chiral organization of DNA in phage capsids.

PNAS 102, Nº 26, 9165-9169 (2005)

2004

Sonia Trigueros, Javier Salceda, Ignacio Bermudez, Xavier Fernandez and Joaquim Roca.

Asymmetric removal of supercoils suggests how topoisomerase II simplifies DNA topology.

J. Mol. Biol. Jan 16; 335 (3):723-31 (2004).

2003

Tobias Hanke, Maria J.Ramiro, Sonia Trigueros, Joaquim Roca and Vicente Larraga.

Cloning, functional analysis and post-transcriptional regulation of a type II DNA Topoisomerase from Leishmania infantum. A new potential target for anti parasite drugs.

Nucleic. Acids. Res.  31, Nº16, 4917-4928 (2003).

2002

Sonia Trigueros and Joaquim Roca

A GyrB-GyrA fusion protein expressed in yeast cells is able to remove DNA supercoils but cannot substitute eukaryotic topoisomerase II. 

Genes to Cells Vol. 7, Issue 3, 249-257 (2002).

Sonia Trigueros and Joaquim Roca

Failure to relax negative supercoiling of DNA is a primary cause of mitotic Hyper-recombination in topoisomerase-deficient yeast cells.

J. Biol. Chem.   277, 37207-37211 (2002).

Javier Arsuaga, Mariel Vazquez, Sonia Trigueros, De Witt Sumners, and Joaquim Roca

Knotting probability of DNA molecules confined in restricted volumes: DNA knotting in Phage capsids.

PNAS USA 99, 5373-5377 (2002).

2001

Sonia Trigueros and Joaquim Roca

Circular minichromosomes become highly recombinogenic in topoisomerase-deficient yeast cells.

J. Biol. Chem.  276,  2243-2249  (2001).

Sonia Trigueros, Javier Arsuaga, Maria E. Vazquez, De Witt Sumners and Joaquim Roca

Novel display of knotted DNA molecules by two-dimensional gel electrophoresis.

Nucleic. Acids. Res.  29,Nº13  (2001).

•Ph.D.  (2001). Molecular Genetics. University of Barcelona. Spain

•Master in Biotechnology (1995-1997).  University of Barcelona. Spain.

•Bachelor in Biology (1995).   University of Barcelona. Spain.

1. •Senior Research Associate Postdoc (2007-2008 )
   

Department of Physics. Bionanotechonoly IRC . University of Oxford.

1. •Research Associate Postdoc (2004-2007 )
   

Department of Biochemistry. Microbiology Unit. University of Oxford.

1. •Postdoctoral Research (2001-2004).
   

Molecular Biology Research. Department of Molecular and Cellular Biology MCB. Harvard University

1. •Visiting Researcher (June 2006)
   

Department of Molecular and Cell Biology. University of California,Berkeley, CA

1. •Visiting Researcher (July-September 2005)
   

LMB/NIDDK/NIH5 Center Drive MSC0540. Bethesda, MD USA

1. •Visiting Researcher (2009-2010)
   

CNIC. University of Habana. Cuba

Education

Research Experience

Selected Publications